期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 10, 期 -, 页码 2065-2070出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.10.214
关键词
alpha-amino amidines; iodine; isocyanide; multicomponent reaction; Ugi reaction
资金
- DST-India [GAP 0378]
- 12th Five Year Plan Project Affordable Cancer Therapeutics [ACT-CSC-0301]
- CSIR-New Delhi
A facile and efficient synthetic protocol for the synthesis of alpha-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom economy, wide substrate scope and high yields.
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