期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 9, 期 -, 页码 2097-2102出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.9.246
关键词
alkynes; gold; indoles; multicomponent; spiroindolines; Ugi
资金
- University of Leuven (KU Leuven)
An Ugi four-component reaction of propargylamine with 3-formylindole and various acids and isonitriles produces adducts which are subjected to a cationic gold-catalyzed diastereoselective domino cyclization to furnish diversely substituted spiroindolines. All the reactions run via an exo-dig attack in the hydroarylation step followed by an intramolecular diastereoselective trapping of the imminium ion. The whole sequence is atom economic and the application of a multicomponent reaction assures diversity.
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