期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 8, 期 -, 页码 1601-1609出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.8.183
关键词
automated synthesis; disaccharide building blocks; solid-phase synthesis; sialic acid; sialosides
资金
- Max-Planck Society
- Swiss National Science Foundation [200020-117889]
- National Science Council Taiwan
- Minerva Stiftung
Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl alpha-(2 -> 3) and alpha-(2 -> 6) galactosyl imidates, which, used in combination with the automated platform, provided rapid access to a small library of conjugation-ready sialosides of biological relevance.
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