期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 8, 期 -, 页码 1443-1451出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.8.164
关键词
anhydride opening; catalytic asymmetric Biginelli reaction; organocatalysis; sulfoximines; thioureas
资金
- Fonds der Chemischen Industrie
- Deutsche Forschungsgemeinschaft (DFG) [SPP 1179]
For the first time, chiral sulfoximine derivatives have been applied as asymmetric organocatalysts. In combination with a thiourea-type backbone the sulfonimidoyl moiety leads to organocatalysts showing good reactivity in the catalytic desymmetrization of a cyclic meso-anhydride and moderate enantioselectivity in the catalytic asymmetric Biginelli reaction. Straightforward synthetic routes provide the newly designed thiourea-sulfoximine catalysts in high overall yields without affecting the stereohomogeneity of the sulfur-containing core fragment.
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