Asymmetric organocatalytic decarboxylative Mannich reaction using β-keto acids: A new protocol for the synthesis of chiral β-amino ketones

The first decarboxylative Mannich reaction employing beta-keto acids, catalyzed by cinchonine-derived bifunctional thiourea catalyst has been described. The desired beta-amino ketones were obtained in excellent yields and with moderate to good enantioselectivities.