期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 7, 期 -, 页码 442-495出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.7.57
关键词
five-membered rings; heterocycles; medicinal chemistry; pharmaceuticals; synthesis
资金
- Cambridge European Trust
- Ralph Raphael Studentship Award
- EPSRC
- Royal Society
- BP endowment
- EPSRC [EP/F069685/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F069685/1] Funding Source: researchfish
This review presents a comprehensive overview on selected synthetic routes towards commercial drug compounds as published in both journal and patent literature. Owing to the vast number of potential structures, we have concentrated only on those drugs containing five-membered heterocycles and focused principally on the assembly of the heterocyclic core. In order to target the most representative chemical entities the examples discussed have been selected from the top 200 best selling drugs of recent years.
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