期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 7, 期 -, 页码 1135-1140出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.7.131
关键词
DNA; isocyanide; multicomponent reaction; organocatalysis; peptidomimetic; RNA
资金
- SB RAS [83, 88]
- RFBR [09-04-01483]
The synthesis of new, artificial ribonucleases containing two amino acid residues connected by an aliphatic linker has been developed. Target molecules were synthesized via a catalytic three-component Ugi reaction from aliphatic diisocyanides. Preliminary investigations proved unspecific nuclease activity of the new compounds towards single-stranded RNA and double-stranded circular DNA.
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