期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 7, 期 -, 页码 1636-1642出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.7.192
关键词
marine fungi; natural products; phthalides; polyketides
资金
- National Institute of Mental Health's Psychoactive Drug Screening Program (NIMH PDSP) [HHSN-271-2008-00025-C]
- NIMH, Bethesda MD, USA
- U.S. National Institute of Health drug discovery program
- Virology Branch, National Institute of Allergic and Infectious Diseases, NIAID [NO1-A1-30048, NO1-AI-15435]
- FCT (Science and Technology Foundation, Portugal)
- BMBF [03F0415A]
The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia sp. cf. C. flammea. Culture on a biomalt medium supplemented with sea salt led to the isolation of three new phthalide derivatives, i.e., marilones A-C (1-3), and the known compound silvaticol (4). The skeleton of marilones A and B is most unusual, and its biosynthesis is suggested to require unique biochemical reactions considering fungal secondary metabolism. Marilone A (1) was found to have antiplasmodial activity against Plasmodium berghei liver stages with an IC50 of 12.1 mu M. Marilone B (2) showed selective antagonistic activity towards the serotonin receptor 5-HT2B with a K-i value of 7.7 mu M.
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