期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 5, 期 -, 页码 -出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.5.27
关键词
Candida antarctica lipase B; continuous flow; epoxidation; hydrogen peroxide; lipase; micro reactor; Novozym (R) 435; peracids
资金
- Department of Chemistry at The University of Hull
We report the use of an immobilised form of Candida antarctica lipase B, Novozym (R) 435, in a preliminary investigation into the development of a continuous flow reactor capable of performing the chemo-enzymatic oxidation of alkenes in high yield and purity, utilising the commercially available oxidant hydrogen peroxide (100 volumes). Initial investigations focussed on the lipase-mediated oxidation of 1-methylcyclohexene, with the optimised reaction conditions subsequently employed for the epoxidation of an array of aromatic and aliphatic alkenes in 97.6 to 99.5% yield and quantitative purity.
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