Microwave-assisted [6+4]-cycloaddition of fulvenes and α-pyrones to azulene-indoles:: Facile syntheses of novel antineoplastic agents

A microwave-enhanced [6 + 4]-cycloaddition reaction between 6-aminofulvene and pyrones followed by CO2 extrusion provides azulene-indoles which display interesting antineoplastic activity. (C) 2001 Elsevier Science Ltd. All rights reserved.