期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 123, 期 31, 页码 7626-7629出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja015556g
关键词
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资金
- NIGMS NIH HHS [GM 62998, GM08515, GM 55002, GM 59249] Funding Source: Medline
Efficient recognition of DNA is a prerequisite for the development of biological effectors, including transcription and translation regulators, transfection vectors, and DNA sensors. To provide an effective scaffold for multivalent interactions with DNA, we have fabricated mixed monolayer protected gold clusters (MMPCs) functionalized with tetraalkylammonium ligands that can interact with the DNA backbone via charge complementarity. Binding studies indicate that the MMPCs and DNA form a charge-neutralized, nonaggregated assembly. The interactions controlling these assemblies are highly efficient, completely inhibiting transcription by T7 RNA polymerase in vitro.
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