期刊
BEHAVIOURAL PROCESSES
卷 105, 期 -, 页码 6-14出版社
ELSEVIER
DOI: 10.1016/j.beproc.2014.02.009
关键词
Acute stress; Memory; Mice; Passive avoidance conditioning; Sex differences; Trait anxiety
资金
- Generalitat Valenciana
- Conselleria de Cultura, Educacion y Ciencia
- Pla Valencia de Ciencia i Tecnologia Generalitat Valenciana [GV/2007/302]
- Conselleria de Educacion [PROMETEO/2009/072]
- University of Valencia, Spain [UV-AE-20070201]
The influence of anxiety on the effects of acute stress for the acquisition and retention of passive avoidance conditioned task was evaluated in male and female mice. Animals were categorized as high-, medium-, and low-anxiety according to their performance in the elevated plus-maze test. Subsequently, half of the mice in each group were exposed to an acute stressor and assayed in an aversive conditioning test two days later. Exposure to restraint stress before inhibitory avoidance conditioning had a differential impact on the conditioned response of males and females according to their trait anxiety. The acute stressor significantly altered the conditioned response of mice with a high-anxiety level. The long-term effect of the stressor varied for each sex; high-anxiety stressed males showed an enhanced conditioned response with respect to their controls, whereas high-anxiety stressed females presented an impaired performance. These results lead us to believe that the characterization of individuality is an important factor in understanding the interaction between stress and memory for each sex; the trait anxiety of our animals modulated the effects of stress on the conditioned response so that males and females performed in contrasting manners to the same environmental stimuli and experimental conditions. (C) 2014 Elsevier B.V. All rights reserved.
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