A multiprotein complex that interacts with RNA polymerase II elongator

A three-subunit Hap complex that interacts with the RNA polymerase If Elongator was isolated fi-om yeast. Deletions of genes for two Hap subunits, HAP1 and HAP3, confer pGKL killer-insensitive and weak Elongator phenotypes. Preferential interaction of the Hap complex with free rather than RNA polymerase II-associated Elongator suggests a role in the regulation of Elongator activity.