期刊
JOURNAL OF ORGANOMETALLIC CHEMISTRY
卷 631, 期 1-2, 页码 41-46出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/S0022-328X(01)00987-1
关键词
gold; thiosalicylate; cyclometallated ligands; biological activity; crystal structure
Reactions of the gold(III) dichloride complexes [(N_C)AuCl2] ((N_C) = cycloaurated 2-phenylpyridine, 2-(p-tolyl)pyridine, 2-anilinopyridine or 2-benzylpyridine) with thiosalicylic acid (2-mercaptobenzoic acid, HSC6H4CO2H) and base gives a series of gold(III) thiosalicylate complexes [(N_C)Au(SC6H4CO2)]. A crystal structure determination on the 2-p-tolylpyridine derivative is reported, confirming the presence of a chelating thiosalicylate ligand, with the tolyl and thiolate groups mutually cis, together with a highly puckered gold-thiosalicylate moiety, and a twisted carboxylate group. The activity of the thiosalicylate complexes against P388 leukaemia cells has been determined. (C) 2001 Elsevier Science B.V. All rights reserved.
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