期刊
JOURNAL OF BIOCHEMISTRY
卷 159, 期 4, 页码 387-392出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvv124
关键词
bone; osteoblast; osteoclast; Wnt5a; Wntless
资金
- Ministry of Education, Cultures, Sports, Science and Technology of Japan [25221310, 25293423]
- Grants-in-Aid for Scientific Research [16H05144, 16H02691, 25293423] Funding Source: KAKEN
Wnt ligands play a central role in the development and homeostasis of various organs through beta w-catenin-dependent and -independent signalling. The crucial roles of Wnt/beta-catenin signals in bone mass have been established by a large number of studies since the discovery of a causal link between mutations in the low-density lipoprotein receptor-related protein 5 (Lrp5) gene and alternations in human bone mass. The activation of Wnt/beta-catenin signalling induces the expression of osterix, a transcription factor, which promotes osteoblast differentiation. Furthermore, this signalling induces the expression of osteoprotegerin, an osteoclast inhibitory factor in osteoblast-lineage cells to prevent bone resorption. Recent studies have also shown that Wnt5a, a typical non-canonical Wnt ligand, enhanced osteoclast formation. In contrast, Wnt16 inhibited osteoclast formation through beta-catenin-independent signalling. In this review, we discussed the current understanding of the Wnt signalling molecules involved in bone formation and resorption.
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