期刊
TETRAHEDRON LETTERS
卷 42, 期 33, 页码 5641-5644出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)01101-7
关键词
-
Here we report the synthesis of a cis-dipeptide mimic N-Boc-Phe-[COCN4]-Gly-OBn. 7, containing the non-hydrolysable alpha -keto tetrazole isostere and an unusual 2,5-disubstituted alpha -keto tetrazole-based peptidomimetic, 8. The incorporation of the novel cis-amide bond isostere was achieved via direct alkylation of a precursor five-substituted (1H)-tetrazole. The assignment or the resulting 1,5- and 2,5-tetrazoyl regiomers was based on the first reported X-ray structure analysis of an alpha -keto tetrazole, compound 8. (C) 2001 Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据