期刊
BRITISH MEDICAL JOURNAL
卷 323, 期 7309, 页码 372-374出版社
BRITISH MED JOURNAL PUBL GROUP
DOI: 10.1136/bmj.323.7309.372
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Objective To assess the clinical efficacy and accuracy of an emergency department based six hour rule-out protocol for myocardial damage. Design Diagnostic cohort study. Setting Emergency department of an inner city university hospital. Participants 383 consecutive patients aged over 25 years with chest pain of less than 12 hours' duration who were at low to moderate risk of acute myocardial infarction. Intervention Serial measurements of creatine kinase MB mass and continuous ST segment monitoring for six hours with 12 leads. Main outcome measure Performance of the diagnostic test against a gold standard consisting of either a 48 hour measurement of troponin T concentration or screening for myocardial infarction according to the World Health Organization's criteria. Results Outcome of the gold standard test was available for 292 patients. On the diagnostic test for the protocol, 53 patients had positive results and 239 patients had negative results. There were 18 false positive results and one false negative result. Sensitivity was 97.2% (95% confidence interval 95.0% to 99.0%), specificity 93.0% (90.0% to 96.0%), the negative predictive value 99.6%, and the positive predictive value 66.0%. The positive likelihood ratio was 13.9 and the negative likelihood ratio 0.03. Conclusions The six hour rule-out protocol for myocardial infarction is accurate mad efficacious. It can be used in patients presenting to emergency departments with chest pain indicating a low to moderate risk of myocardial infarction.
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