期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 11, 期 16, 页码 2089-2091出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00374-2
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资金
- NCI NIH HHS [CA51578] Funding Source: Medline
The 17-methoxy group of geldanamycin was substituted with 1,3-diaminopropane and 1,3-diamino-2-hydroxypropane to introduce a primary amino group useful for conjugation with targeting moieties and drug carriers. We have developed a procedure that has provided improved yield and reproducibility of the syntheses. Both geldanamycin derivatives demonstrated antiproliferative activity towards the human ovarian carcinoma cell line, A2780. (C) 2001 Elsevier Science Ltd. All rights reserved.
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