期刊
DEVELOPMENTAL BRAIN RESEARCH
卷 129, 期 2, 页码 211-214出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-3806(01)00213-9
关键词
ketogenic diet; flurothyl; norepinephrine; dopamine beta-hydroxylase; mouse; pediatric epilepsy
资金
- NINDS NIH HHS [K08 NS01974] Funding Source: Medline
Ketogenic diet (KD) is a high fat, low carbohydrate diet used to treat children with epilepsy that are refractory to conventional antiepileptic drugs (AEDs). The anticonvulsant mechanism of the KD is unknown. To determine if the noradrenergic system has a role in mediating the anticonvulsant action of the KD, dopamine beta -hydroxylase knockout (Dbh -/-) mice that lack norepinephrine (NE) and Dbh +/- littermates that have normal NE content were fed either a standard rodent chow or the KD. When exposed to the convulsant flurothyl, Dbh +/- mice fed the KD had significantly longer latencies to myoclonic jerk (MJ) and generalized clonic-tonic (CT) seizures than Dbh +/- mice fed normal chow. In contrast, Dbh mice fed the KD had seizure latencies to both MJ and CT comparable to Dbh -/- mice fed normal chow. These results suggest that an intact, functional noradrenergic nervous system is required for the KD to exert an anticonvulsant effect. Published by Elsevier Science B.V.
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