期刊
ONCOGENE
卷 20, 期 37, 页码 5195-5198出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204646
关键词
prostate cancer; prostate intraepithelial neoplasia; mitochondrial mutations; bodily fluids
资金
- NCI NIH HHS [P01 CA 58184, R01 CA 77664, UO1 CA 84986] Funding Source: Medline
- NIDCR NIH HHS [R01 DE 012488] Funding Source: Medline
We recently demonstrated the existence of specific patterns of somatic mitochondrial DNA (mtDNA) mutations in several cancers. Here we sought to identify the presence of mtDNA mutations in prostate cancer an their paired PIN lesions. The D-loop region, 16S rRNA, and the NADH subunits of complex I were sequenced to identify mtDNA mutations in 16 matched PIN lesions and primary prostate cancers. Twenty mtDNA mutations were detected in the tumor tissue of three patients. Identical mutations were also identified in the PIN lesion from one patient. This patient with multiple point mutations also harbored a high frequency of microsatellite instability (MSI-H) in nuclear mononucleotide repeat markers. Remarkably, identical mutations were also detected in all (3/3) matched urine and plasma samples obtained from these patients. Although mitochondrial mutations are less common in prostate adenocareinoma, they occur early in cancer progression and they can be detected in bodily fluids of early stage disease patients. The identification of MtDNA mutations may complement other early detection approaches for prostate cancer.
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