期刊
ORGANIC LETTERS
卷 3, 期 17, 页码 2657-2660出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol0162217
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资金
- NIGMS NIH HHS [GM47356, GM59907-01] Funding Source: Medline
[GRAPHICS] A library of potential bisubstrate analogue inhibitors (1) targeting sulfotransferase enzymes was generated by the chemoselective ligation of the PAPS mimic 2 with a panel of 447 aldehydes. Preliminary screening has identified compounds that inhibit estrogen sulfotransferase (EST), an enzyme relevant to breast cancer.
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