期刊
NEUROSCIENCE LETTERS
卷 309, 期 3, 页码 207-209出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02083-3
关键词
estrogen receptor alpha knockout; estradiol; hippocampus; synaptic; electrophysiology; mice; non-genomic
资金
- NIA NIH HHS [AG/NS14979] Funding Source: Medline
- NIMH NIH HHS [R01 MH57759, MH12075, MH59891] Funding Source: Medline
Hippocampal slices from rats exhibit a rapid increase in basal synaptic transmission following 17 beta -estradiol (E-2) application. In the current study we examined the role of the classic genomic receptor, estrogen receptor alpha (ER alpha), in mediating E-2 effects on synaptic transmission. E-2 (100 pM) increased the extracellular synaptic response in hippocampal slices from gonadectomized male and female mice lacking a functional ER alpha knockout (ER alpha KO) and wild-type (WT) littermates. No sexually dimorphic differences were observed, however, the increase in the field potential was more pronounced in WT mice. ER antagonists did not block E-2 mediated growth of the synaptic response in ERaKO mice. The results suggest that the rapid effect of E-2 on synaptic transmission is not mediated by ER alpha, however, ER alpha appears to modulate non-genomic influences on synaptic transmission. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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