期刊
PHYTOCHEMISTRY
卷 58, 期 1, 页码 47-51出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0031-9422(01)00173-X
关键词
Hybanthus parviflorus (Mutis ex L. F.) Baill.; Violaceae; violetilla; isolation; primary structure; cyclotides; macrocyclic polypeptides; hypa A; LCQ
Hypa A, a novel macrocyclic polypeptide containing 30 amino acid residues, has been isolated from the n-butanol extract of the Argentine plant Hybanthus parviflorus. The sequence, cyclo-(SCVYIPCTITALLGCSCKNKVCYNGIPCAE), was determined by automated Edman degradation, quantitative amino acid analysis and nanospray MS/MS2. Three intramolecular disulfide bridges stabilize the cyclic peptide backbone of hypa A. Using these structural features to classify the peptide as a cyclotide, we extended the distribution of that substance class to a new genus. and now propose a uniform nomenclature for cyclotides. (C) 2001 Elsevier Science Ltd. All rights reserved.
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