期刊
BEHAVIOURAL PHARMACOLOGY
卷 21, 期 5-6, 页码 394-408出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FBP.0b013e32833c8544
关键词
Alzheimer's disease; animal models; central nervous system; GIP receptor; glucose-dependent insulinotropic polypeptide; mesial temporal lobe epilepsy related to hippocampal sclerosis; neurological diseases; neuroplasticity; Parkinson's disease
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Apoio a Pesquisa Cientifica e Tecnologica do Estado de Santa Catarina (FAPESC)
Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid hormone, secreted from the enteroendocrine K cells, which has insulin-releasing and extra-pancreatic actions. GIP and its receptor present a widespread distribution in the mammalian brain where they have been implicated with synaptic plasticity, neurogenesis, neuroprotection and behavioral alterations. This review attempts to provide a comprehensive picture of the role of GIP in the central nervous system and to highlight recent findings from our group showing its potential involvement in neurological illnesses including epilepsies, Parkinson's disease and Alzheimer's disease. Behavioural Pharmacology 21:394-408 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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