期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 31, 期 5, 页码 563-573出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0891-5849(01)00628-1
关键词
Alzheimer disease; Arctic ground squirrel; oxidative stress; stroke; antioxidants; metabolic suppression; free radicals
资金
- NINDS NIH HHS [NS41069-01, NS-34115, NS38648] Funding Source: Medline
Brains of hibernating mammals are protected against a variety of insults that are detrimental to humans and other nonhibernating species. Such protection is associated with a number of physiological adaptations including hypothermia, increased antioxidant defense, metabolic arrest, leukocytopenia, immunosuppression, and hypocoagulation. It is intriguing that similar manipulations provide considerable protection as experimental treatments for central nervous system injury. This review focuses on neuroprotective mechanisms employed during hibernation that may offer novel approaches in the treatment of stroke, traumatic brain injury, and neurodegenerative diseases in humans. (C) 2001 Elsevier Science Inc.
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