期刊
BEHAVIOURAL NEUROLOGY
卷 21, 期 1-2, 页码 3-12出版社
HINDAWI LTD
DOI: 10.1155/2009/698156
关键词
MRI; Alzheimer's disease; Mild Cognitive Impairment (MCI); morphometry; brain imaging
资金
- National Center for Research Resources [U24 RR021382]
- National Institute on Aging [R01AG22381, K01AG029218]
- Department of Veterans Affairs
- Alzheimer's Disease Neuroimaging Initiative
- NIH [U01 AG024904]
- National Institute of Biomedical Imaging and Bioengineering (NIBIB)
- Wyeth Research
- Bristol-Myers Squibb
- Eli Lilly and Company
- GlaxoSmithKline
- Merck Co. Inc.
- AstraZeneca AB
- Novartis Pharmaceuticals Corporation
- Alzheimer's Association
- Eisai Global Clinical Development
- Elan Corporation plc
- Forest Laboratories
- Institute for the Study of Aging
- U.S. Food and Drug Administration
- Foundation for the National Institutes of Health
- Northern California Institute for Research and Education
- University of California, San Diego
- University of California, Los Angeles
- NATIONAL CENTER FOR RESEARCH RESOURCES [U24RR021382] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG024904, K01AG029218, R01AG022381, U19AG010483, R01AG031224] Funding Source: NIH RePORTER
Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that measures of structural change in mesial and lateral temporal, cingulate, parietal and midfrontal areas may facilitate the assessment of a treatment's ability to halt the progressive structural loss that accompanies clinical decline in MCI. The performance of prediction is likely to continue to improve with the incorporation of measures from other neuroimaging modalities, clinical assessments, and neuromedical biomarkers, as the regional profile of individuals at risk for progression is refined.
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