期刊
APMIS
卷 109, 期 9, 页码 601-606出版社
MUNKSGAARD INT PUBL LTD
DOI: 10.1034/j.1600-0463.2001.d01-181.x
关键词
solitary fibrous tumour; ultrastructure; immunohistochemistry; cytogenetics
Aims: Cytogenetic data on solitary fibrous tumours (SFT) are very limited. We studied a benign pleural SFT for its ultrastructural and immunohistochemical details, and made cytogenetic analyses for comparison with other genetic and ultrastructural studies of SFT Results: Immunohistochemistry showed strong positivities for CD34 and vimentin, but no reactions with anti-cytokeratins and epithelial membrane antigens. Electron microscopy revealed primitive desmosomes in our SFT The results thus evinced fibroblast-like cells with intermediate epithelial-mesenchymal character. Comparative genomic hybridization of the tumour revealed losses of 1p33 --> pter, 17pter-q21, entire copies of chromosomes 19 and 22, and gains of 1p21-p22, 2q23-q32.3, 3p12-q13.2, 4p14-q28, 6p12-q21, 9p21 --> pter and 13q21-q31. Furthermore, there was loss of 20q, as was previously reported elsewhere in a case of benign and a case of malignant SFT Conclusions: The results furnish further evidence of the involvement of -20q in SFT In addition, they show that SFT may have complex genomic imbalances and primitive features, despite having a benign appearance.
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