期刊
BEHAVIOURAL BRAIN RESEARCH
卷 261, 期 -, 页码 282-288出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2013.12.046
关键词
Estrogen receptor beta; Stroke recovery; AC-131; Cerebral ischemia; Hormone therapy; Photothrombosis
资金
- Swedish Research Council [2011-2684, 2011-2652]
- EU 7th workprogram through the European Stroke Network [201024]
- KARO BIO Research foundation
Acute treatment with 17 beta-estradiol provides effective neuroprotection during the first days after acute brain injury, however, effects of chronic activation of estrogen receptor beta (ER beta) on recovery of function after experimental stroke have not been investigated. The present study, therefore, was conducted to test if delayed treatment with the specific ER(3 ligand 4-(1-phenyl-cyclohexyl)-phenol (AC-131) improves recovery of lost neurological function after permanent focal stroke induced by photothrombosis in adult Sprague-Dawley rats. Treatment was initiated on day 2 after photothrombosis and AC-131 (1, 10, and 50 mg/kg) was administered by daily subcutaneous injections for 14 days. On day 2, 4, 6, 8, 11, 14, and 17 after photothrombosis, functional deficits were assessed by the paw placement test, a standardized grip strength test and an adhesive removal test. Daily treatment with AC-131 significantly improved test scores in all three behavioral tests. Importantly, improved function was not associated with a decrease in infarct volume on day 17 after stroke onset. Our results suggest that increased activity of the ERP is involved in mechanisms of stroke recovery. (C) 2014 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据