期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 31, 期 3, 页码 260-272出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911515613098
关键词
Quercetin; nanofibers; electrospinning; poly(lactide-co-glycolide); polycaprolactone; antitumor activity
资金
- Council of Scientific and Industrial Research, Government of India [20-12/2009(ii)EU-IV]
Quercetin is a potent natural antioxidant but has limited therapeutic applications due to its short half-life in body fluids. In order to improve the efficacy of quercetin and overcome its shortcomings, quercetin-encapsulated electrospun poly(lactic-co-glycolic acid)-poly(epsilon-caprolactone) nanofibrous controlled release system was developed using electrospinning technique. Fourier transform infrared spectroscopy, thermogravimetric, and X-ray diffraction analysis suggested the incorporation, thermal stability, and existence of encapsulated quercetin in semicrystalline state in the nanofibers. The release profiles of quercetin from the poly(lactide-co-glycolide)-polycaprolactone nanofibers in phosphate-buffered saline showed controlled release of quercetin up to 120h. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed an evident inhibition effect of quercetin-encapsulated nanofibers against human hepatocellular carcinoma (HepG2), and the inhibition rate of 29%, 72%, and 80.1% were recorded for 1%, 2%, and 4% quercetin-encapsulated nanofibers, respectively. The formulated drug delivery system could be potentially used as an implantable anticancer drug in clinical applications in the future.
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