期刊
NATURE REVIEWS NEUROSCIENCE
卷 2, 期 9, 页码 643-651出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/35090015
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资金
- NEI NIH HHS [R01 EY010329, R01 EY010329-08] Funding Source: Medline
Few proteins have been described functionally in such detail as ion channels. All ion channels open and close their ion-conducting pores, a process referred to as gating. The recent crystallization of the P-loop-containing channel KcsA has cast channel function in a new light. Results relating to a variety of P-loop-containing channels are converging on a common mechanism in which separation of the inner helices that line the pore results in channel opening. At the same time, differences-some subtle and some perhaps more profound-have emerged between channel types. Here we highlight the evidence for a specific conformational change during the gating of cyclic nucleotide-gated channels, and compare and contrast this evidence to that obtained for other channels.
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