期刊
BEHAVIOURAL BRAIN RESEARCH
卷 270, 期 -, 页码 307-315出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2014.05.021
关键词
Posttraumatic stress disorder (PTSD); Meta-analyses; Voxel-based morphometry (VBM); Anterior cingulate cortex (ACC); Insular cortex; Disaster type
资金
- Chinese National Natural Science Foundation [81222018, 81030027, 81227002, 81220108013]
- Support Plan of the Ministry of Science and Technology [2012BAI01B03]
- 863 Program [2008AA02Z408]
- 973 Project [2008CB517407]
- Support Plan of Sichuan [2011SZ0292]
- Distinguished Young Scholars of Sichuan [2011JQ0005]
- Programs for New Century Excellent Talents in University [NCET-10-0596]
Evidence from previous anatomical studies indicate that widespread brain regions are involved in the pathogenesis of posttraumatic stress disorder (PTSD). The aim of the present study was to quantitatively integrate the literature on structural abnormalities seen on individuals with PTSD. Twenty voxel-based analysis studies were analysed through a comprehensive series of meta-analyses. Compared with healthy controls, PTSD patients showed a significant reduction in grey matter (GM) in the left anterior cingulate gyrus (ACC) at the whole-brain level. Several brain regions, including the left ACC, the left insula and the right parahippocampal gyrus were significantly smaller in individuals with PTSD than in trauma-exposed healthy subjects. Furthermore, the clinician-administered PTSD scale scores were negatively correlated with GM in the left ACC and positively correlated with GM in the left insula. In addition, PTSD patients who experienced accidental or non-accidental trauma had anatomical changes in different brain regions. These results suggest that the smaller ACC and insular cortex within the limbic-prefrontal circuit contribute to the pathogenesis of PTSD. Moreover, the PTSD patients with different types of trauma may have different cerebral deficits. (C) 2014 Elsevier B.V. All rights reserved.
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