期刊
BEHAVIOURAL BRAIN RESEARCH
卷 258, 期 -, 页码 153-159出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2013.10.025
关键词
Pyrroloquinoline quinone; NMDA receptors; MK-801; Stereotypical; Cognitive deficits
资金
- National Natural Science Foundation of China [30770602, 81371590]
- Natural Science Foundation of Jiangsu Province, China [BK2010157, BK2011167]
- Jiangsu province science and technology infrastructure
- science and technology public service platform for Molecular nuclear medicine construction, China [BM2012066]
Pyrroloquinoline quinone (PQQ), an essential nutrient, antioxidant, redox modulator, and nerve growth factor, prevents cognitive deficits associated with oxidative stress-induced neurodegeneration. Previous molecular imaging studies also demonstrate that PQQ binds to N-methyl D-aspartate (NMDA) receptors. In this study, we investigated the effects of PQQ on stereotypical behaviors and cognitive deficits induced by MK-801, a non-competitive NMDA antagonist used to model schizophrenia. Mice were given repeated injections of MK-801 (0.5 mg/kg/d) and PQQ (0.2, 2.0, or 20 mu g/kg/d) for 60 days. Behavior was evaluated using a variety of motor, social, and cognitive tests. We found that PQQ administration significantly attenuated MK-801-induced increases in stereotypical behavior and ataxia, suggesting a protective role of PQQ against MK-801-induced neuronal dysfunction and psychiatric disorders. Future studies are necessary to elucidate the underlying mechanisms of PQQ. (C) 2013 Elsevier B.V. All rights reserved.
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