期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 30, 期 3, 页码 289-301出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911515569918
关键词
Graphene oxide; poly-dopamine; biomimetic; mineralization; cell mediated
资金
- Innovation Funding for Technology-based SMEs of Gansu province [1205FCCA277]
- NSFC [21201092, 21401091]
- Fundamental Research Funds for the Central Universities [lzujbky-2012-189, Lzujbky-2014-m02, Lzujbky-2014-190]
We report a biomimetic mineralization of hydroxyapatite induced by poly-dopamine-functionalized reduced graphene oxide (RGO-PDA). Graphene oxide was first simultaneously reduced and surface functionalized by one-step oxidative polymerization of dopamine. The resultant RGO-PDA was further used as a bioinspired surface to mimic the mineralization of hydroxyapatite during bone formation. MC3T3-E1 cells were cultured on the RGO-PDA substrates to observe various cellular activities and hydroxyapatite mineralization. The MC3T3-E1 cells on RGO-PDA substrates show higher cellular activities such as proliferation, adhesion, and osteogenic differentiation over the bare glass and graphene oxide substrates. Those results suggest the potentials of using RGO-PDA as osteogenesis-promoting scaffolds for successful applications in bone tissue regeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据