期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 86, 期 2-3, 页码 627-633出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0162-0134(01)00210-0
关键词
thiophene-2-carbaldehyde thiosemicarbazone; structure-activity correlations
The crystal structure of [Ni(L-III)(2)] (1), where HLIII = thiophene-2-carbaldehyde thiosemicarbazone, consists of monomeric entities where the nickel(II) ions exhibit distorted square planar geometry. The two bidentate thiosemicarbazone ligands are centrosymmetric. (CS)-S-... van der Waals' links and nonbonded intramolecular interactions are present in the structure. The biological activity of 1 is compared to that of the free ligand, and the cobalt (III) (2) and copper(H) (3) derivatives. The observed order of cytotoxicity against melanoma B16F10 and Friend erythroleukemia. cells is: 1 less than or equal to ligand <2 <3. A structure-activity correlation using Extended-Huckel MO calculations is described. (C) 2001 Elsevier Science BY All rights reserved.
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