期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 30, 期 6, 页码 633-648出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911515585185
关键词
Silk fibroin; poly(l-lactide-co-epsilon-caprolactone); electrospinning; nanofibrous membranes; tissue engineering
资金
- National Key Technology RD Program [2012BAI18B06]
- National Natural Science Foundation of China [31470938, 81171473, 11421202, 61227902, 11120101001]
- International Joint Research Center of Aerospace Biotechnology and Medical Engineering from Ministry of Science and Technology of China
- 111 Project [B13003]
- Research Fund for the Doctoral Program of Higher Education of China [20131102130004]
- Fundamental Research Funds for the Central Universities
In recent years, silk fibroin has become one of the most promising tissue engineering materials because of its excellent cytocompatibility. Poly(l-lactide-co-epsilon-caprolactone), the copolymer of poly(l-lactide) and poly(epsilon-caprolactone), possesses good mechanical properties, and its degradation rates can be manipulated by varying the ratio of the constituent polymers. In this study, in order to combine their respective characteristics, silk fibroin/poly(l-lactide-co-epsilon-caprolactone) nanofibrous membranes were fabricated through electrospinning with different mass ratios of 100:0, 75:25, 50:50, 25:75, and 0:100. The surface properties, thermodynamic properties, mechanical properties, and cytocompatibility of silk fibroin/poly(l-lactide-co-epsilon-caprolactone) blended membranes were evaluated, and an optimal blending ratio was identified. The results showed that the silk fibroin/poly(l-lactide-co-epsilon-caprolactone) blended membranes containing 75% of silk fibroin and 25% of poly(l-lactide-co-epsilon-caprolactone) achieved the most improved performances compared with the single-component membranes or the blended membranes with other mixing ratios. The results from this study indicated that 75/25 silk fibroin/poly(l-lactide-co-epsilon-caprolactone) blended membranes which combined the advantages of poly(l-lactide-co-epsilon-caprolactone) and silk fibroin might be a suitable candidate material for use in tissue engineering.
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