期刊
JOURNAL OF DERMATOLOGICAL SCIENCE
卷 27, 期 1, 页码 27-30出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0923-1811(01)00121-9
关键词
psoriasis; erythrocyte membrane fluidity; electron paramagnetic resonance
类别
The aim of the study was to find the cause of membrane fluidity decrease in psoriasis, observed by other authors, in different types of cells and its clinical consequences. To this end. we have examined the influence of different clinical and biochemical factors on erythrocyte membrane fluidity changes in psoriatic patients. Membrane fluidity was studied by the electron paramagnetic resonance spin-labeling method. The data revealed that the decrease of membrane fluidity corresponded with exacerbation of skin lesions, The results clearly indicate that the increased lipid peroxidation may be the essential mechanism of membrane fluidity decrease in psoriasis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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