期刊
BEHAVIOURAL BRAIN RESEARCH
卷 256, 期 -, 页码 27-35出版社
ELSEVIER
DOI: 10.1016/j.bbr.2013.07.045
关键词
Nicotine; Prepulse inhibition; Magnetoencephalography; Auditory change-related cortical response; Change-N1m; Startle
资金
- Center for Multidisciplinary Brain Research
- National Institutes for Physiological Sciences (NIPS)
- Smoking Research Foundation
- Grants-in-Aid for Scientific Research [25351001] Funding Source: KAKEN
Prepulse inhibition (PPI) of startle is a measure of inhibitory function in which a weak leading stimulus suppresses the startle response to an intense stimulus. Usually, startle blink reflexes to an intense sound are used for measuring PPI. A recent magnetoencephalographic study showed that a similar phenomenon is observed for auditory change-related cortical response (Change-N1m) to an abrupt change in sound features. It has been well established that nicotine enhances PPI of startle. Therefore, in the present magnetoencephalographic study, the effects of acute nicotine on PPI of the Change-N1m were studied in 12 healthy subjects (two females and 10 males) under a repeated measures and placebo-controlled design. Nicotine (4 mg) was given as nicotine gum. The test Change-N1m response was elicited with an abrupt increase in sound pressure by 6 dB in a continuous background sound of 65 dB. PPI was produced by an insertion of a prepulse with a 3-dB-louder or 6-dB-weaker sound pressure than the background 75 ms before the test stimulus. Results show that nicotine tended to enhance the test Change-N1m response and significantly enhanced PPI for both prepulses. Therefore, nicotine's enhancing effect on PPI of the Change-N1m was similar to that on PPI of the startle. The present results suggest that the two measures share at least some mechanisms. (C) 2013 Elsevier B.V. All rights reserved.
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