期刊
BEHAVIOURAL BRAIN RESEARCH
卷 242, 期 -, 页码 110-116出版社
ELSEVIER
DOI: 10.1016/j.bbr.2012.12.041
关键词
Chronic stress; Cytokines; Depression; IDO; Swimming exercise
资金
- National Basic Research Program of China [2007CB512303]
- Natural Science Foundation of China [30900434, 31100840, 31271270]
- Technology Commission of Shanghai Municipals [09XD1405600, 09ZR1439800, 11ZR1446700]
- Key Laboratory of Exercise and Health Sciences of Ministry of Education of Shanghai University of Sport [yk2012008]
Chronic stress is involved in development of depression and causes immune alterations. Indoleamine-2,3-dioxygenase (IDO) plays a pivotal role in mediating the depression-like behaviors in response to immune activation. Physical exercise has been shown to reduce the stress impairment and ameliorate depressive symptoms. The objectives of present study were to confirm that chronic unpredictable mild stress (CUMS) induces depression-like behavior and inflammatory responses within the brain, and then investigate whether swimming exercise alleviates the depression-like behaviors induced by CUMS through proinflammatory cytokine-induced alteration of IDO in brain. It has been found that CUMS exposure induced depression-like behavior, increased serum corticosterone (CORT) level, decreased 5-HT level, increased IFN-gamma and TNF-alpha levels and elevated IDO activity in prefrontal cortex. Moreover, the level of 5-HT was inversely correlated with IDO level. Regular swimming exercise ameliorated depressive symptoms induced by CUMS. The exercise reduced serum CORT level, increased 5-HT level as well as decreased levels of IFN-gamma, TNF-alpha and IDO in prefrontal cortex in CUMS rats. These findings suggested that CUMS activate HPA axis and induce immune activation, which may stimulate IDO activity, leading to the reduction of 5-HT level in brain, thereby resulting in depression. Swimming exercise may inhibit activation of inflammation/IDO pathways induced by CUMS, thereby ameliorating depression. (C) 2013 Elsevier B.V. All rights reserved.
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