期刊
BEHAVIOURAL BRAIN RESEARCH
卷 245, 期 -, 页码 120-127出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2013.02.008
关键词
Alzheimer's disease; Transgenic APP(Swe)/PS1 Delta E9 mice; Behaviour; Social recognition memory; Sensorimotor gating; Cheeseboard
资金
- Schizophrenia Research Institute
- NSW Ministry of Health
- Motor Neuron Disease Research Institute of Australia
- National Health and Medical Research Council (NHMRC) [1045643]
- Australian Research Council [FT0991986]
- NHMRC [630445, 1003886]
- University of New South Wales
- Neuroscience Research Australia
- Australian Research Council [FT0991986] Funding Source: Australian Research Council
- National Health and Medical Research Council of Australia [630445] Funding Source: NHMRC
In order to better understand animal models of Alzheimer's disease, novel phenotyping strategies have been established for transgenic mouse models. In line with this, the current study characterised male APPxPS1 transgenic mice on mixed C57BL/6JxC3H/HeJ background for the first time for social recognition memory, sensorimotor gating, and spatial memory using the cheeseboard test as an alternative to the Morris water maze. Furthermore, locomotion, anxiety, and fear conditioning were evaluated in transgenic and wild type-like animals. APPxPS1 males displayed task-dependent hyperlocomotion and anxiety behaviours and exhibited social recognition memory impairments compared to wild type-like littermates. Spatial learning and memory, fear conditioning, and sensorimotor gating were unaffected in APPxPS1 transgenic mice. In conclusion, this study describes for the first time social recognition memory deficits in male APPxPS1 mice and suggests that spatial learning and memory deficits reported in earlier studies are dependent on the sex and genetic background of the APPxPS1 mouse line used. Furthermore, particular test conditions of anxiety and spatial memory paradigms appear to impact on the behavioural response of this transgenic mouse model for Alzheimer's disease. (C) 2013 Elsevier B.V. All rights reserved.
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