期刊
BEHAVIOURAL BRAIN RESEARCH
卷 240, 期 -, 页码 95-102出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2012.11.025
关键词
Running; Metabolism; Glucose transporter; Hippocampus; Cerebellum; Motor cortex; Plasticity; GLUT
资金
- Natural Sciences and Engineering Council of Canada
Glucose, the predominant energy substrate of the central and peripheral nervous system, is delivered to neurons via a family of facilitative glucose transporters (GLUT). The majority of glucose is transported to the brain via glucose transporter 1 (GLUT1) located on epithelial cells of capillaries and on the astrocytes that wrap around them. Changes in neuronal activity are linked to increases in glucose demand and local cerebral glucose utilization. Current research has indicated a corresponding change in GLUT1 expression in response to increased metabolic demand in operant tasks. The purpose of this study was to examine, in the mouse brain, the effects of neuronal activation induced by voluntary running on the plastic expression of vascular GLUT1 and neuronal plasticity as measured by the microtubule protein beta-tubulin III (Tuj). The results showed that access to a running wheel for 48 h induced plastic changes in the expression of GLUT1, Tuj and GLUT1-associated estimate of astrocyte vascular endfeet in motor regions. The results tend to support the plastic association between mechanisms of energy supply and plastic reorganization of neurons following a new training experience. (C) 2012 Elsevier B.V. All rights reserved.
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