期刊
BEHAVIOURAL BRAIN RESEARCH
卷 250, 期 -, 页码 62-73出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2013.04.049
关键词
Object recognition memory; Habituation; Sensitization; Scent marking; Rabbit; Short term memory
资金
- Consejo Nacional de Ciencia y Tecnologia (CONACyT), Mexico [129381]
The spontaneous response to novelty is the basis of one-trial object recognition tests for the study of object recognition memory (ORM) in rodents. We describe an object recognition task for the rabbit, based on its natural tendency to scent-mark (chin) novel objects. The object recognition task comprised a 15 min sample phase in which the rabbit was placed into an open field arena containing two similar objects, then removed for a 5-360 min delay, and then returned to the same arena that contained one object similar to the original ones (Familiar) and one that differed from the original ones (Novel), for a 15 min test phase. Chin-marks directed at each of the objects were registered. Some animals received injections (sc) of saline, ketamine (1 mg/kg), or MK-801 (37 mu g/kg), 5 or 20 min before the sample phase. We found that chinning decreased across the sample phase, and that this response showed stimulus specificity, a defining characteristic of habituation: in the test phase, chinning directed at the Novel, but not Familiar, object was increased. Chinning directed preferentially at the novel object, which we interpret as novelty-induced sensitization and the behavioral correlate of ORM, was promoted by tactile/visual and spatial novelty. ORM deficits were induced by pre-treatment with MK-801 and, to a lesser extent, ketamine. Novel object discrimination was not observed after delays longer than 5 min. These results suggest that short-term habituation and sensitization, not long-term memory, underlie novel object discrimination in this test paradigm. (c) 2013 Elsevier B.V. All rights reserved.
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