4.6 Article

Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)

期刊

BEHAVIOURAL BRAIN RESEARCH
卷 234, 期 2, 页码 334-342

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2012.07.004

关键词

Alzheimer models; Transgenic; Amyloid-beta; Tau; Anxiety; Sensorimotor systems; Memory; Open-field; Elevated plus-maze; Object recognition; Left-right discrimination; Rotorod; Hot-plate; SHIRPA

向作者/读者索取更多资源

3xTg-AD mutant mice are characterized by parenchymal A beta plaques and neurofibrillary tangles resembling those found in patients with Alzheimer's disease. The mutants were compared with non-transgenic controls in sensorimotor and learning tests. 3xTg-AD mutants were deficient in T-maze reversal, object recognition, and passive avoidance learning. In addition, the mutants showed hypoactivity in two open-field tests, fewer fecal boli in an observation jar, and reduced enclosed arm entries and head-dipping in the elevated plus-maze. On the contrary, the mutants did not differ from controls in pain thresholds, nest-building, and various reflexes determined by the SHIRPA primary screen and were even better on the rotorod test of motor coordination. (C) 2012 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据