A novel 1: 1 complex of potassium mikanin-3-O-sulfate with methanol

Mikanin-3-O-sulfate (1), in the form of its potassium salt, together with mikanin (2) and alpinetin (3) were isolated from Mikania micrantha. The crystal structures of K(1). CH3OH, 2 and 3 .H2O were established by Xray crystallography. The potassium ions in K(1). CH3OH are bridged by O5, O7 and O8 to form a chain of face-sharing KO8 coordination polyhedra, from which the aglycon units are outstretched to form a polymeric molecular column. Adjacent molecular columns are linked by pi-pi stacking between parallel, intercalating aglycon units to form layers matching the (10 (1) over bar) family of planes, which are further interconnected into a three-dimensional supramolecular assembly. Sulfation at 3-OH induced better co-planarity and conjugation of the rings.