期刊
BEHAVIOURAL BRAIN RESEARCH
卷 227, 期 2, 页码 470-479出版社
ELSEVIER
DOI: 10.1016/j.bbr.2011.07.012
关键词
Adult neurogenesis; Dentate gyrus; Cognitive function; Behavior
资金
- NIH [HD069184, NS048271, NS047344, AG024984, MH087874]
- Korea Research Foundation [KRF-2008-357-E00001]
- Maryland Stem Cell Research Fund [RFA-MD-09-3]
- Maryland Stem Cell Research Foundation
- National Research Foundation of Korea [2008-357-E00001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Adult-born neurons are continuously generated and incorporated into the circuitry of the hippocampus throughout life in mammals. Cumulative evidence supports a physiological role for adult-born neurons, yet it not clear whether this subset of dentate granule cells makes a unique contribution to hippocampal function. Perturbation or ablation of adult hippocampal neurogenesis leads to deficits in the acquisition of learned associations or memory recall, whereas an increase in adult hippocampal neurogenesis enhances some forms of learning and memory. The observed effects thus far appear to be task-dependent, species-specific, and sensitive to the timing of manipulations. Here, we review the recent evidence correlating adult-born dentate granule cells (DGCs) with hippocampal-dependent behavior and focus on the dynamic properties of this neuronal population that may underlie its function. We further discuss a framework for future investigations of how newly integrated neurons may contribute to hippocampal processing using advanced genetic techniques with enhanced temporal resolution. (C) 2011 Elsevier B.V. All rights reserved.
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