期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 291, 期 4, 页码 243-250出版社
URBAN & FISCHER VERLAG
DOI: 10.1078/1438-4221-00127
关键词
ADP-ribosylation; Clostridium difficile; Clostridium botulinum; mono-glucosylation; Rho proteins
The Rho GTPases, which belong to the Ras superfamily of low-molecular-mass GTP-binding proteins, are the preferred intracellular targets of bacterial protein toxins. The Rho GTPases RhoA/B/C, Rac1/2 and Cdc42 are the master regulators of the actin cytoskeleton. Clostridium difficile toxins A and B, the causative agents of the antibiotic-associated pseudomembranous colitis, are intracellularly acting cytotoxins which mono-glucosylate the Rho GTPases. Clostridium botulinum C3 toxin, which is not related to the clostridial neurotoxins, catalyses ADP-ribosylation of RhoA/B/C but not of other Rho GTPases. Glucosylation as well as ADP-ribosylation result in functional inactivation of Rho causing disassembly of the actin cytoskeleton.
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