期刊
BEHAVIOURAL BRAIN RESEARCH
卷 234, 期 2, 页码 278-284出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2012.06.027
关键词
Learned helplessness; Stress; Adolescence; Serotonin; Social interaction; Stressor controllability
资金
- National Institute of Health [MH050479, MH082453]
Adolescence is a developmental period in which brain structures involved with stress responses, such as the medial pre-frontal cortex (mPFC), mature. Therefore, exposure to a stressor at this time may have effects that endure the lifespan. The goal of the present study was to determine whether behavioral control over an adolescent stressor mitigates the behavioral and neurochemical consequences of the stressor as occurs in adult rats. Adolescent rats (post natal day 35) were exposed to either inescapable (IS) or escapable tailshocks (ES). As in adults we observed a stressor controllability effect: IS reduced social exploration and activated the serotonergic dorsal raphe nucleus while ES did not. Excitotoxic lesions of the medial prefrontal cortex prevented the stressor controllability effect. We also demonstrate that a controllable adolescent stress prevents the behavioral and neurochemical consequences of IS in adulthood. Thus, the controllability of a stressor during adolescence is an important psychological factor. Published by Elsevier B.V.
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