期刊
BEHAVIOURAL BRAIN RESEARCH
卷 231, 期 2, 页码 317-322出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2012.02.034
关键词
Animal models; Parkinson's disease; Behavioral tests
资金
- NIH/NINDS [NS077022-01]
- Gardner Family Center for Parkinson's Disease and Movement Disorders at University of Cincinnati
- Davis Phinney Foundation
- NIH/National Institute on Deafness and Other Communication Disorders [P30DC010744]
In Parkinson's disease both limb and cranial sensorimotor functions are impaired, leading to a profound diminished quality of life for many patients. Toxin and genetic animal models of Parkinson's disease are likely essential for understanding the pathology associated with these impairments as well as for the development and testing of potential therapeutics. Here we describe useful novel and established behavioral outcome measures for assessing limb and cranial sensorimotor functions in toxin and genetic models of parkinsonism in rats and mice. (C) 2012 Elsevier B.V. All rights reserved.
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