期刊
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
卷 71, 期 3, 页码 401-403出版社
BRITISH MED JOURNAL PUBL GROUP
DOI: 10.1136/jnnp.71.3.401
关键词
Creutzfeldt-Jakob disease; Alzheimer's disease; tau protein; beta-amyloid 1-42
The aim was to quantify tau protein and beta -amyloid (A beta 42) in the CSF of patients with sporadic Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), and controls. Double sandwich enzyme linked immunosorbent assays (ELISAs) were used for measurments. Tau was increased 58-fold in CJD and 3.5-fold in AD compared with controls, whereas A beta 42 was decreased 0.5-fold in both CJD and AD. A cut off level for tau protein at 2131 pg/ml successfully discriminated CJD from AD (100% specificity and 93% sensitivity). Tau protein concentration in CSF is probably an additional useful marker in differentiating CJD from AD.
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