期刊
BEHAVIOURAL BRAIN RESEARCH
卷 216, 期 2, 页码 666-672出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2010.09.010
关键词
Amnestic mild cognitive impairment; Alzheimer's disease; Functional connection; Longitudinal
资金
- National Natural Science Foundation of China [30825014, 30971016]
- National Basic Research Program of China (973 Program) [2007CB512308]
- National Hi-Tech Research and Development Program of China (863 Program) [2008AA02Z413]
- National Key Technologies RD Program [2006BAI02B01]
- Scientific Research of Foundation of Graduate of School of Southeast University [YBJJ0824]
Amnestic mild cognitive impairment (aMCI) patients are thought to be particularly vulnerable to convert to clinical AD where functional disconnection is a major feature of the cortical neuropathology. However, the presence and extent of whole-brain connectivity disturbances is largely unknown in aMCI patients. Twenty-six aMCI patients and eighteen matched healthy subjects were evaluated at baseline and at mean 20 months follow up. Temporal correlations between spatially distinct regions were evaluated by using longitudinal resting-state fMRI. Compared to normal aging controls, patterns of abnormal interregional correlations in widely dispersed brain areas were identified in the patients, which also changed with disease progression. These disturbances were found particularly in subcortical regions and frontal cortex. Importantly, significantly decreased negative functional connection may be specifically associated with the development of aMCI patients. This suggests a compensatory mechanism is underway where local processing deficits are offset by recruitment of more dispersed cortical regions. In addition, the presence of this increased connectivity is seen to eventually weaken with disease progression. The results suggest that patterns of whole-brain functional connection may be a useful risk marker for conversion to AD in aMCI patients. (C) 2010 Elsevier B.V. All rights reserved.
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