期刊
BEHAVIOURAL BRAIN RESEARCH
卷 222, 期 1, 页码 1-9出版社
ELSEVIER
DOI: 10.1016/j.bbr.2011.03.031
关键词
Parkinson's disease; 6-OHDA; Gait pattern; Dopaminergic neurons
资金
- National Science Council [NSC 96-2628-E-269-001-MY3]
- National Health Research Institutes of Taiwan [NHRI-EX98-9535EI]
- Engineering and Physical Sciences Research Council [EP/H010432/1, EP/G049459/1] Funding Source: researchfish
- EPSRC [EP/H010432/1, EP/G049459/1] Funding Source: UKRI
- Direct For Biological Sciences
- Division Of Environmental Biology [1110521] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1257476] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien [1101934] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1005751] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Physics [1126251] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0827725, 0932556] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0846562, 1031329] Funding Source: National Science Foundation
- Directorate For Geosciences
- Division Of Ocean Sciences [1040597] Funding Source: National Science Foundation
- Div Atmospheric & Geospace Sciences
- Directorate For Geosciences [0944101, 1061998] Funding Source: National Science Foundation
- Division Of Computer and Network Systems
- Direct For Computer & Info Scie & Enginr [0831785] Funding Source: National Science Foundation
- Division Of Environmental Biology
- Direct For Biological Sciences [1237517] Funding Source: National Science Foundation
- Division Of Materials Research [1101934] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1105672] Funding Source: National Science Foundation
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [0915100, 0839966] Funding Source: National Science Foundation
- Division Of Ocean Sciences
- Directorate For Geosciences [0963392] Funding Source: National Science Foundation
- Division Of Research On Learning
- Direct For Education and Human Resources [0814881] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1055974] Funding Source: National Science Foundation
Gait disturbances similar to those of human Parkinson's disease (PD) can be observed in animals after administration of neurotoxin 6-hydroxydopamine (6-OHDA) to induce unilateral nigrostriatal dopamine depletion. However, the relationship between gait disturbances and dopamine depletion following 6-OHDA infusion has not been determined. The present study investigated the longitudinal changes of spatiotemporal gait patterns using a walkway system to acquire footprints and lateral limb images over a 6-week period following unilateral 6-OHDA injection into the medial forebrain bundle of rats. Our results indicated that hemiparkinsonian rats exhibited changes in gait patterns, as compared to normal controls, and pre-lesion levels, including a significantly decreased walking speed and step/stride length as well as an increased base of support and foot angle. The relative percentage of the gait cycle was also altered, showing an increase in the stance to swing ratio, which was more evident in the affected hindlimb. Time-course observations showed that these gait disturbances occurred as early as 4 days post-lesion and gradually increased up to 42 days post-injury. The extents of gait disturbances were compared with conventional apomorphine-induced turning behavior and akinesia bar tests, which were also apparent at 4 days post-lesion but remained relatively unchanged after 28 days. Our time-course gait analysis of a unilateral 6-OHDA rodent model provides insight into the compensatory changes of motor functions during the 6-week development of a nigrostriatal lesion, which might be useful for future objective assessment of novel treatments for human PD subjects. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
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